Immunology

Gastrointestinal immunology and allergy

Immune dysfunction in allergic diseases like asthma and atrophy seems to be associated with differences within the function and composition of the gut micro biome. The gut micro biome constitutes a highly complex ecosystem which incorporates eukaryotic fungi, viruses, and a few Achaea, although bacteria are the foremost prominent components. Its composition is usually formed during the primary 3 years of life; however, recent work has suggested that its colonization may begin in utero , contrary to the widely held dogma of the foetus as a sterile environment. Despite its early formation, its composition is very dynamic and hooked in to host-associated factors like age, diet, and environmental conditions with the main phyla being Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria. The gut micro biome isn't homogeneous throughout the GIT, showing higher diversity within the mouth and intestine, and lower diversity within the stomach, mainly due to the acid environment. Symptoms caused by immediate sensitivity within the alimentary canal typically develop within minutes to 2 hours of ingesting the offending food. Symptoms can include lip, tongue and palatal pruritus and swelling, laryngeal oedema, nausea, abdominal cramping, vomiting and diarrhoea. Severe reactions may result in most or all symptoms related to anaphylaxis.

• Cross-contamination
• Facial angioedema
• Tingling of the lips, tongue, palate and throat.
• Oropharyngeal itching
• Anaphylaxis