Immunology

Aging and Immunosenescence

Aging and Immunosenescence refers to the gradual deterioration of the immune system associated with aging. This process results in decreased immune responsiveness, making older individuals more susceptible to infections, diseases, and reduced vaccine efficacy. Key aspects include the decline in the production of new immune cells, impaired function of existing immune cells, and an increase in pro-inflammatory status, often termed "inflammaging." Immunosenescence affects both innate and adaptive immunity, leading to diminished pathogen clearance and a higher prevalence of chronic diseases. Understanding these changes is crucial for developing interventions to enhance immune function in the elderly.