Immunohistochemistry is basically most common application of immunostaining. It also involves the process of selectively of identifying antigens in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in the biological tissues. Immunohistochemistry takes its name from the roots of the "Immuno", in reference to the antibodies used in the procedure, and "histo", which means tissue. Albert Coons coined  the procedure in 1941.Immunohistochemical staining is mainly used in the diagnosis of abnormal cells best known example of that is cancerous tumors. Specific molecular markers are contains characteristic of particular cellular events such as proliferation or cell death.

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